If you consider yourself a biohacker, then maintaining healthy lifestyle routines and habits is important to you, especially when planning a trip. You’ll want to find the easiest ways to stay on top of your nutrition, fitness, sleep, stress, and immune health while navigating the unpredictability of travel and new environments. That’s why researching hotel chains that cater to health-conscious travelers is key—so you won’t miss a beat, even on the road.
Below is LocalsInsider’s list of hotels found in many major cities that support wellness-focused lifestyles. Each one offers a unique blend of health-centric amenities, tech features, and restorative environments designed for travelers who value performance, recovery, and longevity.
Equinox Hotels
Equinox Hotels are tailored to fitness-forward travelers who want more than just a place to sleep. These hotels offer a range of biohacking-friendly amenities such as blackout rooms for optimized sleep, in-room cryotherapy access, and well-stocked minibars filled with electrolyte drinks and collagen shots. With a massive gym and recovery-focused services, it’s a playground for those who track and optimize their performance. Currently, Equinox Hotels are only available in New York City, but future expansions are in the works.
Six Senses Hotels and Resorts
Six Senses is a luxury hotel brand that puts wellness at the forefront. Their properties provide guests with options like sleep tracking, guided meditation, and personalized spa treatments. Many locations include in-room wellness kits and curated menus featuring whole, nutritious foods. Found in cities like Rome, London, and Bangkok, Six Senses is an excellent choice for travelers seeking a deeper mind-body connection, as well as a five-star experience that doesn’t compromise on health.
1 Hotels
Known for sustainability and wellness, 1 Hotels optimize indoor air quality with purification systems and promote eco-conscious living. Rooms often include organic cotton linens, yoga mats, and even Peloton bikes in some locations. Hotel restaurants offer clean, plant-based meals with locally sourced ingredients, making it easy to stay on track with healthy eating. With properties in NYC, LA, Nashville, Miami, and Toronto, 1 Hotels are ideal for environmentally aware biohackers who want holistic comfort, from food to sleep.
Even Hotels (IHG)
Even Hotels, part of the IHG group, are built for travelers who want to maintain fitness routines with minimal effort. Rooms come equipped with resistance bands, balance balls, yoga mats, and guided workout videos. Guests also benefit from mood lighting that supports sleep cycles and healthy grab-and-go food options perfect for business travelers on tight schedules. Even Hotels are located in key U.S. cities including New York, Washington DC, Seattle, and Miami.
Zedwell Hotels
Zedwell Hotels prioritize sleep—arguably the most important pillar of wellness. These London-based properties offer rooms without windows to block light and noise, alongside mood-enhancing aromatherapy and calming interior design. Some rooms also exclude TVs and Wi-Fi, promoting a true digital detox. Zedwell is perfect for travelers who want to reset their sleep patterns or simply prioritize deep rest while staying in a central location.
Chenot Clinics
Chenot Clinics offer some of the most advanced wellness programs in the world—rooted in science, longevity, and performance optimization. The flagship location in Weggis, Switzerland is especially known for its “fake fasting” protocol, a carefully designed plant-based diet of around 850 calories per day that mimics the effects of fasting to stimulate cellular repair, detox, and anti-inflammatory benefits.
Alongside the nutrition plan, guests undergo hydrotherapy, cryotherapy, stress testing, body composition analysis, and targeted treatments designed to promote longevity and energy optimization.
Chenot also operates properties in Montenegro and Gabala, Azerbaijan, with plans to expand to other wellness-forward destinations. Prices for week-long programs start around $8,000–$11,000, depending on the level of medical testing and therapies selected. It’s a favorite for entrepreneurs, executives, and wellness enthusiasts who want results-driven health transformations.
Clinique La Prairie
Clinique La Prairie, based in Montreux, Switzerland, is a pioneer in luxury medical wellness and longevity science. Guests come for programs focused on revitalization, detox, immune boosting, and biological age reversal. Each stay includes bloodwork, consultations with medical doctors, tailor-made nutrition, and wellness treatments such as cryotherapy, high-tech spa services, and IV infusions. Their goal? To extend healthspan through science-backed protocols that blend Eastern and Western techniques.
In addition to Switzerland, Clinique La Prairie now has wellness centers in Madrid, and is opening locations in Bangkok, Doha, Taipei, and Anji, China. Prices vary by package but typically start at $15,000 USD per week, with high-end experiences running up to $40,000+ USD. It’s one of the most exclusive—and effective—retreats for biohackers focused on longevity, cellular health, and elite diagnostics.
We hope this list helps you feel more confident about sticking to your health and wellness goals while traveling. With options that range from in-room fitness equipment to full-scale longevity diagnostics and therapeutic fasting, there’s something here for every kind of biohacker. Bookmark this list for your next big trip and check your destination for nearby options—you may find yourself optimizing more than just your itinerary.
